After making those changes your touchpad will now be disabled every time you connect a mouse to your laptop.Change the value from 0 to 1 and close Registry Editor.Open Registry Editor and go to HKEY_CURRENT_USER/Software/Elantech/Othersetting/DisableWhenDetectUSBMousekey in the left pane.If that doesn't work or isn't available, a registry edit should be the solution for us, I'd personally suggest a registry backup by clicking on file and export before performing the below steps, to be on a safer side: Locate Disable internal pointing device when the external USB pointing device is attached option and enable it.When the Mouse settings window opens, you should see the ELAN or Device Settings tab.When Control Panel opens, go to Hardware and Sound section and select Mouse.Press Windows Key + X to open the Win + X menu and select Control Panel from the list.If it's an ELAN Touchpad, use the below steps:
Depending on which touchpad driver you have, please follow the below registry edits to disable the touchpad, ensure you create an export (backup) of the registry before you make the changes: